I made the jump. And I can't be happier. OSX is far superior in terms of stability to the average user... (Yes, a PC can be stable, but you have to be a real proactive user or have a friend to do that). Personally, I regard myself as a advanced user, but I don't want to spend time on anti-viruses, spyware and so on. On the Mac, I don't have to worry about this...
The nice thing about Macs is the Mac community. Dedicated Mac users will help other Mac users. Also, there are far more free/open source high quality applications then for Windows (signal VS. noise, my PC comrades  )...
The Mac isn't perfect obcourse, but Apple has far more control over it's product making it a full package. The hardware and software are made to work together... And as Bmelton said, since there's Bootcamp, as well as Parallels (a similar, third party app that runs Vista in OSX, like Virtual PC did, but far faster), you can always access Vista when needed.
The one problem about switching I do see is for Adobe product users, expecially Photoshop users. PS isn't Intel native yet, it can be emulated via Rosetta (a technology to run old PPC Mac apps on Intel Macs), but is slow. If you use Photoshop a lot, wait till it goes native for Intel Macs. As for other applications, most of the software you'll need is Intel native (you can see a list of Intel-ready software on Macupdate.com).
If you have any other questions, feel free to ask. I can also recommend good software and things that a Mac "newbie" should know (for example that alt+switch+2 is @  )...
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