I think the only consideration is the SEO implications of typing out the title of the site on the site itself, in external links, etc. Certain keywords do get more searches in their singular or plural forms; check out this Google Trends comparison for Font vs. Fonts.
Google Trends: font, fonts
The search engine probably won't care about the "s" in the domain itself, but it will notice the "s" or lack thereof in any backlinks where you type out the site title, and it will associate either Font or Fonts with your site based on the text in those links. Since more people are searching Font than Fonts, you'd be better off associating your site with the keyword Font than Fonts. Of course, if you're not going to type out the site title in backlinks, it probably won't matter much.
In any event, I would recommend doing a trends search and factoring the results into your decision--it can't hurt.
Tom
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