I am going to make a permanent link for my articles is it possible
i.e. I am going to make ‘http://www.mydomain.com/article.aspx?id=15” to “http://www.mydomain.com/1500.aspx
Is it possible?

Yes, it's possible.
This is best done in the Application_BeginRequest routine in global.asax.
You can read the URL that was requested like this:

  Dim CurrentHTTP As HttpContext = HttpContext.Current
  Dim RequestedPath As String = CurrentHTTP.Request.Path

Then you'd have your logic to work out where it's going... and then all you need to do is re-write the path, i.e.

CurrentHTTP.RewritePath("/folder/page.aspx?ID=" & ID)

Thanks For your Reply,
but would you please write it in Simple steps,Which I Follow.

- Open global.asax (or if it doesn't exist, create it. global.asax should reside in the web application root)
- In the function Application_BeginRequest, add the code from my first code block above (Again, if the function doesn't exist, create it. Here's a template: )

    Public Sub Application_BeginRequest(ByVal sender As Object, ByVal e As System.EventArgs)
        ' Code goes here...
    End Sub

- At this point, the variable RequestedPath will hold the value of the path that was initially requested, for example "/1500.aspx"
- You then need some code to work out where that path should actually be going. That's up to you.
- Then you just need to use CurrentHTTP.RewritePath(NewPath) replacing NewPath with whatever you worked out the new path to be.