I'm using a WP_Query object to create two loops. The goal is to have a full post on the first page, with 3 excerpts following it.
The rest of the pages are then to display only excerpts. The first page works fine, but then each page that follows displays only the excerpts that were on the first page!
If anyone could tell me where I'm going wrong that'd be great.
Here are the loops I'm using:

PHP Code:

<?php
        if ($paged == 0) :
            $posts = new WP_Query();
            $posts->query('showposts=1&cat=-10&orderby=date');
        ?>

        <?php if($posts->have_posts()) : ?><?php while($posts->have_posts()) : $posts->the_post(); ?>
                    <div class="entry">
                        <div id="h1-wrapper">
                          <h1><a href="<?php the_permalink(); ?>"><?php the_title(); ?></a> <span class="date"><?php the_date(); ?></span></h1>
                        </div>
                        <div class="detail">Filed under <?php the_category(', '); ?>, posted by <a href="#">Matt</a></div>
                        <div class="content">
                            <?php the_content(); ?>
                        </div>
                    </div>
        <?php endwhile; ?>
        <?php endif; ?>   

        <?php endif; ?>   

        <?php
            $posts = new WP_Query();
            $posts->query('cat=-10&offset=1&orderby=date');
        ?>

        <?php if($posts->have_posts()) : ?><?php while($posts->have_posts()) : $posts->the_post(); ?>
                    <div class="entry">
                        <div id="h2-wrapper">
                          <h2><a href="<?php the_permalink(); ?>"><?php the_title(); ?></a> <span class="date"><?php the_date(); ?></span></h2>
                        </div>
                        <div class="detail">Filed under <?php the_category(', '); ?>, posted by <a href="#">Matt</a></div>
                        <div class="content">
                            <?php the_excerpt(); ?>
                        </div>
                    </div>
        <?php endwhile; ?>
        <?php endif; ?>        

        <div id="post-nav">
          <?php posts_nav_link('&nbsp;', 'Previous', 'Next'); ?>
        </div>

Check the page on The Loop at the WordPress Codex. About midway down the page it talks about multiple loops.

I think all you need to do is use different variable names each time you call WP_Query() instead of setting both to $posts. If not try calling rewind_posts(); before calling the second loop

Also don't hold me to this, but I think if you let the first loop run without calling WP_Query() and then do what you're doing in the second post it will work.

Your paging is not working properly because you have <?php posts_nav_link('&nbsp;', 'Previous', 'Next'); ?> after the last <?php endif; ?>. Everything you want to do with a loop must be done within the loop.

Try this:
<?php endwhile; ?>
<div id="post-nav">
<?php posts_nav_link('&nbsp;', 'Previous', 'Next'); ?>
</div>
<?php endif; ?>