I know so many people still using 800 x 600 and so I still believe that you should be designing for this res if a fixed layout is what you're going for.
Using an 800 x 600 screen and coming across a website that has been designed for a bigger screen is quite frustrating. Go 800 x 600.
However, if you're website is aimed at a design audience there will surely be less people on a smaller res. Right? Hmm.
Research your audience, I guess.
*shrug* 
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