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First post!
Yes, leave it blank. With the navigation on top, there's no problem with whitespace.
Another issue is that you may want to specify a max-width for your container div. The reason is that some people have widescreen monitors (1440x900 px+) and really wide rows of text becomes difficult to read after a while. Consider upping the readability of your one column by making the lines smaller. This may seem a little awkward putting even more whitespace at the edges of your pages, but I think that it improves readbillity drastically.
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