I'll cast the first byte
I don't like the combined fonts used in the right side of your header, especially the quote. Why don't you put the advert in that area and reduce the header size in the same time.. or at least center the advert.
The links in the top-div could be a bit larger. You need to style the images in your posts and lose the dotted underline which disappears on hover. Try to use the same color of links in the sidebar.
Image optimization on the main page could save ya 467.9KB (63% reduction). There are other optimization techniques you could use as well but that's not related to design.
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